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Science 15 October 1971:
Vol. 174. no. 4006, p. 292
DOI: 10.1126/science.174.4006.292
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Articles

Norepinephrine Stimulated Increase of Cyclic AMP Levels in Developing Mouse Brain Cell Cultures

Nicholas W. Seeds 1 and Alfred G. Gilman 2

1 Departments of Biophysics and Genetics and Psychiatry, University of Colorado Medical Center Denver 80220
2 Laboratory of Biochemical Genetics, National Heart and Lung Institute, Bethesda, Maryland 20014

Norepinephrine causes a four- to sixfold increase in the intracellular level of cyclic AMP (adenosine 3', 5'-monophosphate) reaggregated brain cell cultures derived from embryonic mouse brain. The cyclic AMP level of adult brain is increased by norepinephrine; however, embryonic mouse brain does not show a cyclic AMP response. The aggregate cultures thus demonstrate an event of differentiation very similar to that seen in vivo.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)