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Science 1 October 1971:
Vol. 174. no. 4004, pp. 58 - 59
DOI: 10.1126/science.174.4004.58
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Articles

Intrarenal Formation of Angiotensin I

Harold D. Itskovitz 1 and Charles Odya 1

1 Department of Medicine, Medical College of Wisconsin, Milwaukee 53233

In 5 patients and 16 dogs the mean concentration of angiotensin I, but not II, was higher in the plasma of the renal vein than in the plasma of the renal artery. The fact that I was higher in the vein than in the artery supports the concept that I is formed in the renal vasculature. In the vein the mean concentration of I was 45 times higher than that of II. The probable formation of angiotensin I within the kidney and its high concentration in the renal vein suggest that if the renin angiotensin system plays a role in the regulation of intrarenal blood flow, then angiotensin I may be the major effector hormone in this process.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Regulation of Cardiovascular Signaling by Kinins and Products of Similar Converting Enzyme Systems: ACE and non-ACE mediated effect of angiotensin I on intracellular calcium mobilization in rat glomerular arterioles.
J. Marchetti, C. M. B. Helou, C. Chollet, R. Rajerison, and F. Alhenc-Gelas (2003)
Am J Physiol Heart Circ Physiol 284, H1933-H1941
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Science. ISSN 0036-8075 (print), 1095-9203 (online)