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Science 24 September 1971:
Vol. 173. no. 4003, pp. 1243 - 1245
DOI: 10.1126/science.173.4003.1243
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Articles

Nonencapsidated Infectious DNA of Adeno-Satellite Virus in Cells Coinfected with Herpesvirus

D. Wark Boucher 1, Joseph L. Melnick 1, and Heather D. Mayor 1

1 Department of Virology and Epidemiology, Baylor College of Medicine, Houston, Texas 77025

Adeno-associated satellite viruses produce antigen detectable by immunofluorescence but not infectious virus in tissue culture cells coinfected with herpes simplex virus. Analysis of DNA extracts from these infected cells shows that large amounts of infectious satellite virus DNA are produced but not encapsidated in the system. This result indicates that satellite virus may be defective at the maturation step.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)