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Science 10 September 1971:
Vol. 173. no. 4001, pp. 1026 - 1028
DOI: 10.1126/science.173.4001.1026
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Articles

Reversible Osmotic Opening of the Blood-Brain Barrier

Stanley I. Rapoport 1, Masaharu Hori 2, and Igor Klatzo 2

1 Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda,Maryland 20014
2 Laboratory of Neuropathology and Neuroanatomical Sciences, National Institute of Neurological Disease and Stroke,Bethesda 20014

Reversible breakdown of the blood-brain barrier is produced by a class of electrolytes and nonelectrolytes which have little or no lipid solubility but which difler in chemical and ionic properties. These agents may osmotically shrink barrier cells, possibly the vascular endothelium, and reversibly open spaces between them. Lipid-soluble nonelectrolytes damage the barrier irreversibly.


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