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Science 3 September 1971:
Vol. 173. no. 4000, pp. 923 - 925
DOI: 10.1126/science.173.4000.923
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Articles

Calcium Requirement for Melanophore-Stimulating Hormone Action on Melanophores

David L. Vesely 1 and Mac E. Hadley 2

1 Department of Biological Sciences and College of Medicine, Unniversity of Arizona, Tucson 85721
2 Department of Biological Sciences, University of Arizona

The calcium ion is specifically required for the action of melanophorestimulating hormone on melanosome dispersion within lizard (Anolis carolinensis) melanophores in vitro. The response to this hormone is directly related to the concentration of the Ca2+ ion. Lithium, choline, rubidium, and cesium will replace the sodium and potassium of Ringer solution if Ca2+ is present. Calcium ions are not required for melanosome dispersion itself, since theophylline or dibutyryl cyclic adenosine monophosphate reversibly darkens lizard skins in the absence of calcium.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Calcium-dependent prolonged effects on melanophores of [4-norleucine, 7-D-phenylalanine]-alpha-melanotropin.
M. Hadley, B Anderson, C. Heward, T. Sawyer, and V. Hruby (1981)
Science 213, 1025-1027
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Science. ISSN 0036-8075 (print), 1095-9203 (online)