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Science 27 August 1971:
Vol. 173. no. 3999, pp. 847 - 849
DOI: 10.1126/science.173.3999.847
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Articles

Effects of Long-Term Reserpine Treatment on Brain Tyrosine Hydroxylase and Behavioral Activity

David S. Segal 1, John L. Sullivan III 1, Ronald T. Kuczenski 1, and Arnold J. Mandell 1

1 Department of Psychiatry, University of California, San Diego, La Jolla 92037

Treatment of rats with reserpine (for 8 or 9 days) produced a temporally related increase in behavioral activity and in tyrosine hydroxylase activity in the midbrain. Weight loss resulting from such treatment was not sufficient, by itself, to account for either the behavioral or enzymatic changes. The results support the role of catecholamines in behavioral arousal.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Strain differences during intraventricular infusion of norepinephrine: possible role of receptor sensitivity.
D. Segal, M. Geyer, and B. Weiner (1975)
Science 189, 301-303
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Short- and Long-Term Lithium Administration: Effects on the Brain's Serotonergic Biosynthetic Systems.
S. Knapp and A. J. Mandell (1973)
Science 180, 645-647
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Narcotic Drugs: Effects on the Serotonin Biosynthetic Systems of the Brain.
S. Knapp and A. J. Mandell (1972)
Science 177, 1209-1211
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Thyroid State: Effects on Pre-and Postsynaptic Central Noradrenergic Mechanisms.
W. Emlen, D. S. Segal, and A. J. Mandell (1972)
Science 175, 79-82
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