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Science 27 August 1971:
Vol. 173. no. 3999, pp. 843 - 845
DOI: 10.1126/science.173.3999.843
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Articles

Latent Herpes Simplex Virus in Spinal Ganglia of Mice

Jack G. Stevens 1 and Margery L. Cook 1

1 Department of Medical Microbiology and lmmunology, and Reed Neurological Research Center, University of California School of Medicine, Los Angeles 90024

Herpes simplex virus establishes a persistent, latent infection in spinal ganglia after mice have recovered from posterior paralysis. Infectious virus is replicated when these ganglia are explanted and maintained as organ cultures in vitro.


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