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Science 27 August 1971:
Vol. 173. no. 3999, pp. 840 - 841
DOI: 10.1126/science.173.3999.840
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Articles

Subacute Sclerosing Panencephalitis: Isolation of Suppressed Measles Virus from Lymph Node Biopsies

Luiz Horta-Barbosa 1, Rebecca Hamilton 1, Barbara Wittig 1, David A. Fuccillo 1, John L. Sever 1, and Mina Lee Vernon 2

1 Section On Infectious Diseases, Perinatal Research Branch, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland 20014
2 Microbiological Associates, Inc., Bethesda

Measles virus was isolated in mixed cultures of lymph node cells and HeLa cells. The agent was isolated by cocultivation from biopsy specimens of two of five patients with subacute sclerosing panencephalitis. The virus was identified by hemagglutination-inhibition, immunofluorescent, and neutralization tests. Biopsies from controls did not show evidence of measles virus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Studies on the Interactions between Viruses and Lymphocytes.
B. R. Bloom, A. Senik, G. Stoner, G. Ju, M. Nowakowski, S. Kano, and L. Jimenez (1977)
Cold Spring Harb Symp Quant Biol 41, 73-83
   Abstract »    PDF »
Subacute Sclerosing Panencephalitis: Unusual Nuclear Inclusions and Lengthy Clinical Course.
M. Dubois-Dalcq, J. M. Coblentz, and A. B. Pleet (1974)
Arch Neurol 31, 355-363
   Abstract »    PDF »


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