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Science 27 August 1971:
Vol. 173. no. 3999, pp. 827 - 829
DOI: 10.1126/science.173.3999.827
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Articles

Leucylglycinamide Released from Oxytocin by Human Uterine Enzyme

Roderich Walter 1, H. Shlank 1, J. D. Glass 1, I. L. Schwartz 1, and T. D. Kerenyi 1

1 Departments of Physiology and Obstetrics and Gynecology, Mount Sinai Medical and Graduate Schools, City University of New York, New York 10029

Uteri of pregnant and nonpregnant women contain enzymic activities which inactivate oxytocin. A potent enzyme, which has been partially purified from uterine homogenates, cleaves the prolyl-leucyl peptide bond of oxytocin. This findinig associates for the first time the release of the dipeptide leucylglycinamide with the degradation of neurohypophyseal hormones.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)