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Science 20 August 1971:
Vol. 173. no. 3998, pp. 742 - 743
DOI: 10.1126/science.173.3998.742
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Articles

Cell Dissociation: Univalent Antibodies as a Possible Alternative to Proteolytic Enzymes

H. Beug 1, G. Gerisch 1, and E. Müller 1

1 Friedrich-Miescher-Laboratorium, der Max-Planck-Gessellschaft, 74 Tübingen, Germany

Univalent antibody fragments directed against special membrane antigens dissociate multicellular bodies of the cellular slime mold Dictyostelium discoideum completely into single cells. This provides a gentle method for cell dissociation and demonstrates that a nonenzyme protein can disintegrate a tissue

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Science. ISSN 0036-8075 (print), 1095-9203 (online)