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Science 20 August 1971:
Vol. 173. no. 3998, pp. 736 - 738
DOI: 10.1126/science.173.3998.736
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Articles

Biological Activity and Synthesis of an Encephalitogenic Determinant

R. Shapira 1, F. C-H. Chou 1, S. McKneally 1, E. Urban 1, and R. F. Kibler 1

1 Departments of Biochemistry and Medicine, Emory University, Atlanta, Georgia 30322

A 45-residue fragment of the basic protein of myelin is encephalitogenic in the rabbit and monkey but relatively inactive in the guinea pig. Synthetic peptides containing the sequence of a tryptic peptide of the fragment Thr-Thr-His-Tyr-Gly-Ser-Leu-Pro-Gln-Lys are moderately encephalitogenic.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Sequence homology between certain viral proteins and proteins related to encephalomyelitis and neuritis.
U Jahnke, E. Fischer, and E. Alvord Jr (1985)
Science 229, 282-284
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Experimental Allergic Encephalomyelitis in the Rat: Response to Encephalitogenic Proteins and Peptides.
D. E. McFarlin, S. E. Blank, R. F. Kibler, S. McKneally, and R. Shapira (1973)
Science 179, 478-480
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Science. ISSN 0036-8075 (print), 1095-9203 (online)