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Science 6 August 1971:
Vol. 173. no. 3996, pp. 540 - 542
DOI: 10.1126/science.173.3996.540
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Articles

Adenosine 3',5'-Monophosphate Phosphodiesterase: Multiple Molecular Forms

Eirik Monn 1 and Robert O. Christiansen 1

1 Department of Pediatrics, Stanford University School of Medicine and Stanford Medical Center, Stanford, California 94305

By starch-gel electrophoresis and a specific staining technique, seven different molecular forms of cyclic nucleotide phosphodiesterase have been demonstrated in supernatants from homogenates of rat and rabbit tissues. No tissue contains more than four components, but there are distinct differences in component patterns among the various tissues. Tentative molecular weights of the three most prevalent components of rat tissues have been estimated at 135,000, 150,000, and 167,000 by sucrose density gradient centrifugation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cyclic AMP Phosphodiesterase in Cloned Astrocytoma Cells: Norepinephrine Induces a Specific Enzyme Form.
P. Uzunov, H. M. Shein, and B. Weiss (1973)
Science 180, 304-306
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