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Science 23 July 1971:
Vol. 173. no. 3994, pp. 340 - 343
DOI: 10.1126/science.173.3994.340
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Articles

Ribosome-Catalyzed Polyester Formation

Stephen Fahnestock 1 and Alexander Rich 1

1 Department of Biology, Massachusetts Institute of Technology, Cambridge 02139

Deamination of phenylalanyl-transfer RNA with nitrous acid yields the agr-hydroxyacyl analog, phenyllactyl-transfer RNA. When this is incubated in a protein-synthesizing system directed by polyuridylic acid, it yields an acid-precipitable, alkali-labile polyester of phenyllactic acid.


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