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Science 16 July 1971:
Vol. 173. no. 3993, pp. 249 - 251
DOI: 10.1126/science.173.3993.249
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Articles

Acetoxycycloheximide Enhances Audiogenic Seizures in DBA/2J Mice

H. D. Jameson 1, P. Falace 1, A. Prerost 1, and G. Clemons 1

1 Departments of Neurology and Physiology and Biophysics, University of Kentucky, Lexington 40506

Inborn errors of metabolism often cause epilepsy, as with certain strains of mice. Aggravating the metabolic defect with a protein synthesis inhibitor increases the symptoms. Mature animals that have "outgrown" their genetic susceptibility to audiogenic seizures are made susceptible again by acetoxycycloheximide. After a single small dose the incidence and severity of audiogenic seizures increases at 16 hours, reaches a maximum of 40 hours, and then declines gradually.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)