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Science 2 July 1971:
Vol. 173. no. 3991, pp. 62 - 64
DOI: 10.1126/science.173.3991.62
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Articles

Teratogenic Effects of a Chelating Agent and Their Prevention by Zinc

Helene Swenerton 1 and Lucille S. Hurley 1

1 Department of Nutrition, University of California, Davis 95616

Ingestion of a chelating agent (ethylenediaminetetraacetic acid) by female rats during pregnancy impaired reproduction and resulted in congenitally malformed young. When ethylenediaminetetraacetic acid was fed from days 6 to 21 of gestation, all of the full-term young had gross congenital malformations. These effects were prevented by simultaneous supplementation with 1000 parts per million of dietary zinc.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Final Report on the Safety Assessment of EDTA, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, Disodium EDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA, Trisodium EDTA, HEDTA, and Trisodium HEDTA.
(2002)
International Journal of Toxicology 21, 95-142
   Abstract »    PDF »
Influence of Simultaneous Supplementation of Zinc and Copper During Chelation of Lead in Rats.
S. J. S. Flora (1991)
Human and Experimental Toxicology 10, 331-336
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)