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Science 18 June 1971:
Vol. 172. no. 3989, pp. 1265 - 1267
DOI: 10.1126/science.172.3989.1265
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Articles

Production of Hemadsorption-Negative Areas by Serums Containing Australia Antigen

David H. Carver 1 and Dexter S. Y. Seto 1

1 Departments of Pediatrics and Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Exposure of human Wi-38 cells to human serums containing Australia antigen, and presumably serum hepatitis virus, renders the cells refractory to infection by Newcastle disease virus as detected by the hemadsorption-negative plaque test for intrinsic interference. Induction of the Newcastle disease virus refractory state could be passed in cell culture with up to a 1 : 100,000 dilution of material obtained from cells "infected" with serums containing Australia antigen after filtration (0.45-µm pores) and heating to 60°C for 1 hour. Human antiserums to the Australia antigen prevented induction of the Newcastle disease virus refractory state.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)