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Science 11 June 1971:
Vol. 172. no. 3988, pp. 1158 - 1159
DOI: 10.1126/science.172.3988.1158
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Articles

Marihuana Components: Effects of Smoking on Dgr9-Tetrahydrocannabinol and Cannabidiol

Frantiscaronek Mikescaron 1 and Peter G. Waser 1

1 Institute of Pharmacology, University of Zürich, 8006 Zürich, Switzerland

Cigarettes impregnated with various preparations of Dgr9-tetrahydro-cannabinol (Dgr9-THC) and cannabidiol were artificially smoked, and the smoke was analyzed by means of gas chromatography and a combination of gas chromatography and mass spectrometry. Retention of the two test substances in smoke was 21 to 23 percent of the starting amount. The ratio of Dgr9-THC to cannabidiol in smoke is different from that in starting material. It is suggested that these differences are the result of partial cyclization of the cannabidiol to Dgr9-THC. An increase in the percentage of cannabinol in smoke is the result of a partial dehydrogenation drogenation of Dgr9-THC or cannabidiol. No evidence for the isomerization of Dgr9-THC to Dgr8-THC or for the formation of new pyrolyzed products was found.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
In Vitro Contamination of Hair by Marijuana Smoke.
J. Thorspecken, G. Skopp, and L. Potsch (2004)
Clin. Chem. 50, 596-602
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Science. ISSN 0036-8075 (print), 1095-9203 (online)