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Science 11 June 1971:
Vol. 172. no. 3988, pp. 1150 - 1151
DOI: 10.1126/science.172.3988.1150
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Articles

Amyloid Fibril Proteins: Proof of Homology with Immunoglobulin Light Chains by Sequence Analyses

G. G. Glenner 1, W. Terry 1, M. Harada 1, C. Isersky 1, and D. Page 1

1 National Institutes of Health, Bethiesda. Maryland 20014

The sequences of the 35 and 36 amino-terminal amino acids of two purified amyloid fibril proteins have been determined. Results indicate that these two proteins are derived from homogeneous immunoglobulin light chains of variable region subgroup VkgrI. The relation between amyloidosis and immunoglobulins is thus more firmly established.


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