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Science 4 June 1971:
Vol. 172. no. 3987, pp. 1034 - 1036
DOI: 10.1126/science.172.3987.1034
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Articles

Calcium: Is It Required for Transmitter Secretion?

David M. J. Quastel 1, John T. Hackett 1, and J. David Cooke 2

1 Department of Pharmacology, University of British Columbia, Vancouver 8
2 Department of Physiology, Dalhousie University, Halifax, Nova Scotia

Ethanol multiplies miniature end-plate potential frequency independently of calcium ion concentrations and also multiplies calcium-dependent depolarization-evoked quantal release, to the same extent. This result implies a final common pathway, requiring little or no calcium, for both kinds of transmitter secretion. Chlorpromazine and hypertonicity act similarly to ethanol, but also depress depolarization-secretion coupling.


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