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Science 21 May 1971:
Vol. 172. no. 3985, pp. 851 - 854
DOI: 10.1126/science.172.3985.851
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Articles

DNA Polymerase Required for Rapid Repair of X-ray—Induced DNA Strand Breaks in vivo

Christopher D. Town 1, Kendric C. Smith 1, and Henry S. Kaplan 1

1 Department of Radiology, Stanford University School of Medicine, Stanford, California 94305

A much higher yield of DNA single-strand breaks was obtained in the DNA polymerase-deficient mutant Escherichia coli K-12 pol A1 after a given dose of x-rays than had been found before in Escherichia coli. The increased yield of single-strand breaks was due to the absence of a rapid repair system, which had not been described in Escherichia coli K-12. This absence probably accounts for the x-ray sensitivity of the pol A1 mutant. The rapid repair system can be reversibly inhibited in pol+ cells.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)