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Science 21 May 1971:
Vol. 172. no. 3985, pp. 850 - 851
DOI: 10.1126/science.172.3985.850
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Articles

DNA (Cell Number) in Neonatal Brain: Second Generation (F2) Alteration by Maternal (F0) Dietary Protein Restriction

Stephen Zamenhof 1, Edith van Marthens 1, and Ludmila Grauel 2

1 Department of Medical Microbiology and Immunology, Department of Biological Chemistry, Brain Research Institute, and Mental Retardation Center, University of California School of Medicine, Los Angeles 90024
2 Department of Medical Microbiology and Immunology, Department of Biological Chemistry, Brain Research Institute, and Mental Retardation Center, University of California School of Medicine, Los Angeles 90024

Female rats were maintained on a protein-restricted diet 1 month prior to mating and throughout pregnancy. Their female offspring were maintained on a normal diet from birth or from weaning and were mated with normal males. The second generation offspring at birth still had significantly lower cerebral weight and total cerebral DNA (cerebral cell number).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Gestational zinc deprivation in mice: persistence of immunodeficiency for three generations.
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Prenatal Cerebral Development: Effect of Restricted Diet, Reversal by Growth Hormone.
S. Zamenof, E. van Marthens, and L. Grauel (1971)
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