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Science 30 April 1971:
Vol. 172. no. 3982, pp. 490 - 492
DOI: 10.1126/science.172.3982.490
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Articles

Lymphocyte Stimulation: Selective Destruction of Cells during Blastogenic Response to Transplantation Antigens

Sydney E. Salmon 1, Randall S. Krakauer 1, and Willet F. Whitmore 1

1 Cancer Research Institute and Department of Medicine, School of Medicine, University of California, San Francisco 94122

The blastogenic response of human lymphoid cells toward any individual's transplantation antigens can be deleted by the addition of tritiated thymidine of high specific activity during the incubation of the lymphoid cells in mixed leukocyte culture. After the immunocompetent clones which responded to histocompatibility antigens had been destroyed, the remaining population still retained its capacity to respond to unrelated antigens, including other transplantation antigens.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transplantation of Treated Lymphocytes in Lymphopenic Immunologic Deficiency: Tritiated Thymidine in Mixed Leukocyte Culture for Deletion of Transplantation Antigen Response.
S. E. Salmon, S. N. Mogerman, H. A. Perkins, B. A. Smith, R. I. Lehrer, and H. R. Shinefield (1972)
Arch Pediatr Adolesc Med 123, 111-115
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Science. ISSN 0036-8075 (print), 1095-9203 (online)