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Science 30 April 1971:
Vol. 172. no. 3982, pp. 475 - 478
DOI: 10.1126/science.172.3982.475
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Articles

Cholestasis: Lamellar Structure of the Abnormal Human Serum Lipoprotein

Robert L. Hamilton 1, Richard J. Havel 1, John P. Kane 1, Allen E. Blaurock 1, and Teizo Sata 1

1 Cardiovascular Research Institute and Departments of Anatomy and Medicine, University of California School of Medicine, San Francisco

An abnormal lipoprotein was visualized directly in serum by electron microscopy of preparations negatively stained with potassium phosphotungstate. It appears as a unique disk-shaped particle with major axis measuring 400 to 600 angstroms and minor axis measuring about 100 angstroms. Chemical analysis, viscosity measurements, and x-ray diffraction analysis of purified preparations indicate that the particle, consisting of a one-to-one molar mixture of cholesterol and choline phosphatides associated with a small amount of protein, is a flattened vesicle, the wall of which is a continuous lipid bilayer.


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