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Science 23 April 1971:
Vol. 172. no. 3981, pp. 395 - 398
DOI: 10.1126/science.172.3981.395
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Articles

Developing Neuromuscular Junctions: First Signs of Chemical Transmission during Formation in Tissue Culture

Norman Robbins 1 and Takeshi Yonezawa 1

1 Department of Pathology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto, Japan

Electrophysiological study of rat neuromuscular junctions in the early stage of formation in tissue culture showed that chemical transmission begins with discrete, localized release of transmitter about the time when nerve-muscle contacts are first visible with light microscopy. Noncontractile myotubes with as few as three nuclei showed evidence of junctional transmission.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Choline Acetyltransferase Activity Is Increased in Combined Cultures of Spinal Cord and Muscle Cells from Mice.
E. L. Giller Jr., B. K. Schrier, A. Shainberg, H. R. Fisk, and P. G. Nelson (1973)
Science 182, 588-589
   Abstract »    PDF »
Neurotrophic Effect on Isolated Chick Embryo Muscle in Culture.
T. H. Oh, D. D. Johnson, and S. U. Kim (1972)
Science 178, 1298-1300
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)