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Science 23 April 1971:
Vol. 172. no. 3981, pp. 382 - 383
DOI: 10.1126/science.172.3981.382
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Articles

Immunoglobulin Production by Human Lymphocytoid Lines and Clones: Absence of Genic Exclusion

Arthur D. Bloom 1, Kyoo W. Choi 1, and Barbara J. Lamb 1

1 Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48104

Immunoglobulin production was studied in established lines of normal human lymphocytes. Three lines which produced both immunoglobulin G and immunoglobulin M were cloned. Among the 25 immunoglobulin-producing clones, 23 produced both classes of immunoglobulins. These findings suggest that the phenomenon of genic exclusion does not hold for immunoglobulin production in lymphocytoid cells in culture.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)