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Science 16 April 1971:
Vol. 172. no. 3980, pp. 290 - 292
DOI: 10.1126/science.172.3980.290
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Articles

Alcohol Dependence and Opiate Dependence: Lack of Relationship in Mice

Avram Goldstein 1 and Barbara A. Judson 1

1 Department of Pharmacology, Stanford University, Stanford, California 94305

According to a recently proposed hypothesis, physical dependence upon alcohol is due to the formation of an endogenous opiate. We tested the hypothesis by determining whether or not ethanol-dependent mice would show typical opiate-dependent behavior (withdrawal jumping syndrome) when challenged with the opiate antagonist naloxone. Our results do not support the hypothesis.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)