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Science 16 April 1971:
Vol. 172. no. 3980, pp. 271 - 273
DOI: 10.1126/science.172.3980.271
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Articles

Immunotherapy of Cancer: Regression of Tumors after Intralesional Injection of Living Mycobacterium bovis

Berton Zbar 1 and Tomiko Tanaka 1

1 Cellular Immunity Section, Biology Branch, National Cancer Institute, Bethesda, Maryland 20014

Injection of living Mycobacterium bovis (strain BCG) into established intradermal tumors caused tumor regression and prevented the development of metastases.


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Regression of tumors in guinea pigs after treatment with synthetic muramyl dipeptides and trehalose dimycolate.
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Calmette-Guerin Bacillus Treatment of Experimental Conjunctival Malignant Melanoma.
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Systemic Infection Following BCG Therapy.
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Arch Intern Med 134, 769-770
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Suppression of Urethan-Induced Lung Adenomas in Mice Treated with Trehalose-6,6-Dimycolate (Cord Factor) and Living Bacillus Calmette Guerin.
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Immunotherapy of Cancer: Immunospecific Rejection of Tumors in Recipients of Neuraminidase-Treated Tumor Cells Plus BCG.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)