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Science 16 April 1971:
Vol. 172. no. 3980, pp. 269 - 271
DOI: 10.1126/science.172.3980.269
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Articles

Insulin and Microtubules in Rat Adipocytes

David Soifer 1, Theodor Braun 2, and Oscar Hechter 2

1 Neurochemistry Department, Institute for Basic Research in Mental Retardation, 1050 Forest Hill Road, Staten Island, New York 10314
2 Department of Physiology, Northwestern Medical School, 303 East Chicago Avenue, Chicago, Illinois 60611

Insulin appears to promote microtubule assemblty in rat adipocytes. Neithler oxytocin nor high concentrations of glucose has this effect. Colchicine inihibits stimulation by insulin of lipid and glycogen synthesis without influencing stimulation by insulin of glucose oxidation. The anabolic effects of oxytocin or high concentrations of glucose are not inhibited by colchicine. The "directive effect" of insulin may involve microtubules.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Intracellular Insulin-Responsive Glucose Transporter (GLUT4) Distribution But Not Insulin-Stimulated GLUT4 Exocytosis and Recycling Are Microtubule Dependent.
S. Shigematsu, A. H. Khan, M. Kanzaki, and J. E. Pessin (2002)
Mol. Endocrinol. 16, 1060-1068
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Science. ISSN 0036-8075 (print), 1095-9203 (online)