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Science 9 April 1971:
Vol. 172. no. 3979, pp. 171 - 174
DOI: 10.1126/science.172.3979.171
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Articles

Latent Meiotic Anomalies Related to an Ancestral Exposure to a Mutagenic Agent

K. S. Lavappa 1 and George Yerganian 1

1 Children's Cancer Research Foundation and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

When urethan is administered to cytologically normal F2 progeny descended from grandsires exposed to ethyl methanesulfonate, meiotic anomalies in the forms of site-specific X-chromosome deletions and bivalent associations are noted in spermatocytes of male Armenian hamsters examined 6 and 8 days after treatment, respectively. These latent anomalies are initiated and retained in a premutated state for two generations after the ancestral exposure to ethyl methanesulfonate, the additional impetus required to complete the mutational processes being supplied by urethan.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)