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Science 9 April 1971:
Vol. 172. no. 3979, pp. 165 - 167
DOI: 10.1126/science.172.3979.165
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Articles

Activity of Dgr8-and Dgr9-Tetrahydrocannabinol and Related Compounds in the Mouse

H. D. Christensen 1, R. I. Freudenthal 1, J. T. Gidley 1, R. Rosenfeld 1, G. Boegli 1, L. Testino 1, D. R. Brine 1, C. G. Pitt 1, and M. E. Wall 1

1 Chemistry and Life Sciences Laboratory, Research Triangle Institute, Research Triangle Park, North Carolina 27709

The 11-hydroxy metabolites of Dgr8.- and Dgr9-tetrahydrocannabinol are more active than the parent compounds when administered to mice by either the intravenous or intracerebral route. Both Dgr8- and Dgr9-tetrahydrocannabinol are rapidly and extensively metabolized by the liver and not by the brain. The hypothesis that the 11-hydroxy metabolites may be the active form of tetrahydrocannabinol is discussed


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Delta-9-Tetrahydrocannabinol: Localization in Body Fat.
D. S. Kreuz and J. Axelrod (1973)
Science 179, 391-393
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Intravenous Injection in Man of Dgr9-Tetrahydrocannabinol and 11-OH-Dgr9-Tetrahydrocannabinol.
M. Perez-Reyes, M. C. Timmons, M. A. Ipton, K. H. Davis, and M. E. Wall (1972)
Science 177, 633-635
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11-Hydroxy-Dgr9-tetrahydrocannabinol: Pharmacology, Disposition, and Metabolism of a Major Metabolite of Marihuana in Man.
L. Lemberger, R. E. Crabtree, and H. M. Rowe (1972)
Science 177, 62-64
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Cannabinoids with a Propyl Side Chain in Cannabis: Occurrence and Chromatographic Behavior.
R. A. de Zeeuw, J. Wijsbeek, D. D. Breimer, T. B. Vree, C. A. M. van Genneken, and J. M. van Rossum (1972)
Science 175, 778-779
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Delta-9-Tetrahydrocannabinol: Metabolism and Disposition in Long-Term Marihuana Smokers.
L. Lemberger, N. R. Tamarkin, J. Axelrod, and I. J. Kopin (1971)
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