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Science 9 April 1971:
Vol. 172. no. 3979, pp. 162 - 163
DOI: 10.1126/science.172.3979.162
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Articles

New Class of Purine Mutants of Chinese Hamster Ovary Cells

Milton W. Taylor 1, M. Souhrada 1, and J. McCall 1

1 Department of Microbiology, Indiana University, Bloomington 47401

Mutants of Chinese hamster ovary cells (CHO/Pro-) were isolated after mutagenesis with N-methylnitrosoguanidine and selection by the bromodeoxyuridine technique. Six of these were mutants classified as purine-requiring. The metabolic block appears to be early in the purine biosynthetic pathway. The mutants do not appear to be genetically identical.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)