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Science 9 April 1971:
Vol. 172. no. 3979, pp. 161 - 162
DOI: 10.1126/science.172.3979.161
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Articles

Inhibition of Growth of Leukemia Cells by Enzymic Folate Depletion

J. R. Bertino 1, P. O'Brien 1, and J. L. McCullough 1

1 Departments of Pharmacology and Medicine, Yale University School of Medicine, New Haven, Connecticut 06510

A new bacterial enzyme, designated as carboxypeptidase G1, inhibited growth of the L5178Y and L1210 murine leukemias, as well as the Walker carcinoma and the human lymphoblastoid line (RPMI 4265), propogated in vitro. This enzyme hydrolyzes the glutamate moiety from both oxidized and reduced folate forms, and thus it may prove to be of value in creating rapid folate depletion in vivo.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)