Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 2 April 1971:
Vol. 172. no. 3978, pp. 69 - 72
DOI: 10.1126/science.172.3978.69
Prev | Table of Contents | Next

Articles

Structure of the Hinge Region of the Mu Heavy Chain of Human IgM Immunoglobulins

Claudine Paul 1, Akira Shimizu 1, Heinz Köhler 1, and Frank W. Putnam 1

1 Department of Zoology, Indiana University, Bloomington 47401

The amino acid sequence around the central disulfide bridge linking the mu heavy chains of the human immunoglobulin M monomer is unlike that in immunoglobulin G. This hinge area contains one of the five oligosaccharides of the mu chain, is low in proline, and is the site of tryptic cleavage to yield Fabµ and Fcµ fragments.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Complete Amino Acid Sequence of the Mu Heavy Chain of a Human IgM Immunoglobulin.
F. W. Putnam, G. Florent, C. Paul, T. Shinoda, and A. Shimizu (1973)
Science 182, 287-291
   Abstract »    PDF »
X-Ray Crystallographic Studies of the Fab and Fc Fragments of Human Myeloma Immunoglobulins.
R. J. Poljak, L. M. Amzel, H. P. Avey, L. N. Becka, D. J. Goldstein, and R. L. Humphrey (1972)
Cold Spring Harb Symp Quant Biol 36, 421-425
   Abstract »    PDF »
Variation and Homology in the Mu and Gamma Heavy Chains of Human Immunoglobulins.
A. Shimizu, C. Paul, H. Kohler, T. Shinoda, and F. W. Putnam (1971)
Science 173, 629-633
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)