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Science 19 March 1971:
Vol. 171. no. 3976, pp. 1163 - 1165
DOI: 10.1126/science.171.3976.1163
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Articles

Immunoglobulin M and Secretory Immunoglobulin A: Presence of a Common Polypeptide Chain Different from Light Chains

Jiri Mestecky 1, Jiri Zikan 2, and William T. Butler 3

1 Institute of Dental Research and Department of Microbiology, University of Alabama in Birmingham, Birmingham 35233
2 Division of Clinical Immunology and Rheumatology
3 Institute of Dental Research and Department of Biochemistry

Unique polypeptide chains have been isolated from S-sulfonated light-chain fractions of human serum immunoglobulin M and colostral immunoglobulin A. Their electrophoretic mobilities, molecular weights, peptide maps, amino acid compositions, and antigenic determinants are very similar or perhaps identical but differ from those of light chains and secretory piece.


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