Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 19 March 1971:
Vol. 171. no. 3976, pp. 1151 - 1153
DOI: 10.1126/science.171.3976.1151
Prev | Table of Contents | Next

Articles

Tumor Detection by Nuclear Magnetic Resonance

Raymond Damadian 1

1 Biophysical Laboratory, Department of Medicine, State University of New York, Brooklyn 11203

Spin echo nuclear magnetic resonance measurements may be used as a method for discriminating between malignant tumors and normal tissue. Measurements of spin-lattice (T1) and spin-spin (T2) magnetic relaxation times were made in six normal tissues in the rat (muscle, kidney, stomach, intestine, brain, and liver) and in two malignant solid tumors, Walker sarcoma and Novikoff hepatoma. Relaxation times for the two malignant tumors were distinctly outside the range of values for the normal tissues studied, an indication that the malignant tissues were characterized by an increase in the motional freedom of tissue water molecules. The possibility of using magnetic relaxation methods for rapid discrimination between benign and malignant surgical specimens has also been considered. Spin-lattice relaxation times for two benign fibroadenomas were distinct from those for both malignant tissues and were the same as those of muscle.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
There Is More Than Shape and Function.
M. G. Friedrich (2008)
J. Am. Coll. Cardiol. 52, 1581-1583
   Full Text »    PDF »
Latest Advances in Molecular Imaging Instrumentation.
B. J. Pichler, H. F. Wehrl, and M. S. Judenhofer (2008)
J. Nucl. Med. 49, 5S-23S
   Abstract »    Full Text »    PDF »
Cell water dynamics on multiple time scales.
E. Persson and B. Halle (2008)
PNAS 105, 6266-6271
   Abstract »    Full Text »    PDF »
The (amorphous) anatomy of an invention: the case of magnetic resonance imaging (MRI)..
A. Prasad (2007)
Social Studies of Science 37, 533-560
   Abstract »    PDF »
Neural bases of personal and extrapersonal neglect in humans.
G. Committeri, S. Pitzalis, G. Galati, F. Patria, G. Pelle, U. Sabatini, A. Castriota-Scanderbeg, L. Piccardi, C. Guariglia, and L. Pizzamiglio (2007)
Brain 130, 431-441
   Abstract »    Full Text »    PDF »
Myocardial t1 mapping for detection of left ventricular myocardial fibrosis in chronic aortic regurgitation: pilot study..
P. Sparrow, D. R. Messroghli, S. Reid, J. P. Ridgway, G. Bainbridge, and M. U. Sivananthan (2006)
Am. J. Roentgenol. 187, W630-W635
   Abstract »    Full Text »    PDF »
Magnetic Resonance As a Cancer Imaging Biomarker.
A. G. Sorensen (2006)
J. Clin. Oncol. 24, 3274-3281
   Abstract »    Full Text »    PDF »
Historical Perspectives: The Early Development of Neonatal Magnetic Resonance Imaging.
M. I. Levene (2006)
NeoReviews 7, e329-e333
   Full Text »    PDF »
MR Pulse Sequences: What Every Radiologist Wants to Know but Is Afraid to Ask..
R. Bitar, G. Leung, R. Perng, S. Tadros, A. R. Moody, J. Sarrazin, C. McGregor, M. Christakis, S. Symons, A. Nelson, et al. (2006)
RadioGraphics 26, 513-537
   Abstract »    Full Text »    PDF »
Scientific Culture in the 'Other' Theater of 'Modern Science': An Analysis of the Culture of Magnetic Resonance Imaging Research in India.
A. Prasad (2005)
Social Studies of Science 35, 463-489
   Abstract »    PDF »
Whole body magnetic resonance imaging.
S. J Eustace and E. Nelson (2004)
BMJ 328, 1387-1388
   Full Text »    PDF »
Noninvasive Grading of Untreated Gliomas: A Comparative Study of MR Imaging and 3-(Iodine 123)-L-{alpha}-methyltyrosine SPECT.
B. Riemann, K. Papke, N. Hoess, T. Kuwert, M. Weckesser, P. Matheja, H. Wassmann, W. Heindel, and O. Schober (2002)
Radiology 225, 567-574
   Abstract »    Full Text »    PDF »
Ultrasonic Acupuncture and the Correlation Between Acupuncture Stimulation and the Activation of Associated Brain Cortices Using Functional Magnetic Resonance Imaging.
J. P. Jones (2002)
Bulletin of Science Technology Society 22, 362-370
   Abstract »    PDF »
Normal Brain and Brain Tumor: Multicomponent Apparent Diffusion Coefficient Line Scan Imaging.
S. E. Maier, P. Bogner, G. Bajzik, H. Mamata, Y. Mamata, I. Repa, F. A. Jolesz, and R. V. Mulkern (2001)
Radiology 219, 842-849
   Abstract »    Full Text »    PDF »
Genitourinary Imaging: The Past 40 Years.
S. M. Goldman and C. M. Sandler (2000)
Radiology 215, 313-324
   Abstract »    Full Text »
Magnetic Resonance in Dermatology.
A. Zemtsov and L. Dixon (1993)
Arch Dermatol 129, 215-218
   Abstract »    PDF »
Echo-planar imaging: magnetic resonance imaging in a fraction of a second.
M. Stehling, R Turner, and P Mansfield (1991)
Science 254, 43-50
   Abstract »    PDF »
Mapping the Cerebral Blood Vessels With High-Field MRI: Technical and Anatomic Review.
C. R. Gomez (1989)
Angiology 40, 436-442
   Abstract »    PDF »
Magnetic Resonance Imaging (MRI): A New Tool in Experimental Toxicologic Pathology.
D. Dixon, G. A. Johnson, G. P. Cofer, L. W. Hedlund, and R. R. Maronpot (1988)
Toxicol Pathol 16, 386-389
   Abstract »    PDF »
Magnetic Resonance Imaging of the Brain and Spine: Is Clinical Efficacy Established after the First Decade?.
D. L. KENT and E. B. LARSON (1988)
Ann Intern Med 108, 402-424
   Abstract »    PDF »
Magnetic Resonance Imaging: Prologue.
Council on Scientific Affairs (1987)
JAMA 258, 3283-3285
   Abstract »    PDF »
Proton Magnetic Resonance Spectral Patterns of Metastasizing and Nonmetastasizing Human Colon Cancers.
W. Chen, J. W. Frazer, L. Dennis, C. M. McBride, and A. W. Boddie Jr (1987)
Arch Surg 122, 1284-1288
   Abstract »    PDF »
Magnetic Resonance Imaging of Uveal Melanomas.
R. B. Chambers, F. H. Davidorf, J. F. McAdoo, and D. W. Chakeres (1987)
Arch Ophthalmol 105, 917-921
   Abstract »    PDF »
The Physical State of Intranuclear Water and Ions: Changes During Cell Proliferation and Chemically Induced Carcinogenesis.
C. Nicolini, P. Carlo, and S. Ridella (1987)
Toxicol Pathol 15, 184-189
   Abstract »    PDF »
Nuclear magnetic resonance technology for medical studies.
T. Budinger and P. Lauterbur (1984)
Science 226, 288-298
   Abstract »    PDF »
The Core Curriculum in Diagnostic Radiology Residency Training.
R. M. Heller, C. L. Partain, S. G. Kirchner, A. C. Winfield, J. E. Chapman, and A. E. James JR (1984)
Perspectives in Public Health 104, 111-113
   Abstract »
Nuclear magnetic resonance imaging of the vitreous body.
R. Gonzalez, H. Cheng, P Barnett, J Aguayo, B Glaser, B Rosen, C. Burt, and T Brady (1984)
Science 223, 399-400
   Abstract »    PDF »
Nuclear Magnetic Resonance Techniques in Medicine.
E. M. BRADBURY, G. K. RADDA, and P. S. ALLEN (1983)
Ann Intern Med 98, 514-529
   Abstract »    PDF »
Implications of Nuclear Magnetic Resonance Imaging for the Pediatrician.
R. M. HELLER, C. L. PARTAIN, and A. E. JAMES JR (1982)
Arch Pediatr Adolesc Med 136, 1045-1046
   Abstract »    PDF »
Nuclear Magnetic Resonance Imaging: A Promising Technique.
A. E. James Jr, R. R. Price, F. D. Rollo, J. A. Patton, J. J. Erickson, C. M. Coulam, and C. L. Partain (1982)
JAMA 247, 1331-1334
   Abstract »    PDF »
Positron Tomography and Nuclear Magnetic Resonance Imaging.
G. L. Brownell, T. F. Budinger, P. C. Lauterbur, and P. L. MCGeer (1982)
Science 215, 619-626
   Abstract »    PDF »
Recent developments in nuclear magnetic resonance spectroscopy.
G. Levy and D. Craik (1981)
Science 214, 291-299
   Abstract »    PDF »
NMR opens a new window into the body. The use of nuclear magnetic resonance for medical diagnosis hovers on the brink of practical application.
J. Marx (1980)
Science 210, 302-305
   PDF »
Field focusing nuclear magnetic resonance (FONAR): visualization of a tumor in a live animal.
R Damadian, L Minkoff, M Goldsmith, M Stanford, and J Koutcher (1976)
Science 194, 1430-1432
   Abstract »    PDF »
Bounds on "bound water": transverse nuclear magnetic resonance relaxation in barnacle muscle.
K. Foster, H. Resing, and A. Garroway (1976)
Science 194, 324-326
   Abstract »    PDF »
Phosphorus-31 as a nuclear probe for malignant tumors.
K. Zaner and R Damadian (1975)
Science 189, 729-731
   PDF »
Water in Brain Edema: Observations by the Pulsed Nuclear Magnetic Resonance Technique.
K. G. Go and H. T. Edzes (1975)
Arch Neurol 32, 462-465
   Abstract »    PDF »
Nuclear Magnetic Resonance Studies and Water "Ordering" in the Crystalline Lens.
M. C. Neville, C. A. Paterson, J. L. Rae, and D. E. Woessner (1974)
Science 184, 1072-1074
   Abstract »    PDF »
Proton Relaxation Rates of Water in Brain and Brain Tumors.
R. G. Parrish, R. J. Kurland, W. W. Janese, and L. Bakay (1974)
Science 183, 438-439
   Abstract »    PDF »
Recognition of Cancer in vivo by Nuclear Magnetic Resonance.
I. D. Weisman, L. H. Bennett, L. R. Maxwell Sr., M. W. Woods, and D. Burk (1972)
Science 178, 1288-1290
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)