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Science 12 March 1971:
Vol. 171. no. 3975, pp. 1024 - 1026
DOI: 10.1126/science.171.3975.1024
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Articles

Scanning Electron Microscopic Observations of Surface Structure of Isolated Human Chromosomes

H. M. Golomb 1 and G. F. Bahr 1

1 Biophysics Branch, Armed Forces Institute of Pathology, Washington, D.C. 20305

Isolated human chromosomes dried by the critical-point method have been assumed to retain their original three-dimensional shape when viewed under a transmission electron microscope. Our scanning electron microscopic study confirms this interpretation and reveals an appearance like that of a skein of yarn. The existence of fiber bridges between chromatid pairs and among chromosomes is demonstrated.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Quantitative Constraints in the Arrangement of Human DNA.
E. J. DuPraw (1974)
Cold Spring Harb Symp Quant Biol 38, 87-98
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Science. ISSN 0036-8075 (print), 1095-9203 (online)