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Science 5 March 1971:
Vol. 171. no. 3974, pp. 915 - 917
DOI: 10.1126/science.171.3974.915
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Articles

Penicillin as an Epileptogenic Agent: Effect on an Isolated Synapse

G. F. Ayala 1, W. A. Spencer 2, and R. J. Gumnit 3

1 Department of Neurology, University of Minnesota, Minneapolis 55455
2 Department of Physiology, New York University, and Department of Neurobiology, Public Health Research Laboratories, New York 10016
3 Department of Neurology, St. Paul-Ramsey Hospital, and University of Minnesota, St. Paul 55101

Penicillin enhances the excitatory postsynaptic potential of the squid stellate ganglion. This effect suggests the hypothesis that the epileptic focus created by the topical application of penicillin to the mammalian cerebral cortex is produced by the facilitation of excitatory synaptic coupling within the preexisting positive recurrent feedback system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Penicillin-Induced Segmental Myoclonus: I. Motor Responses and Intracellular Recording From Motoneurons.
L. I. Kao and W. E. Crill (1972)
Arch Neurol 26, 156-161
   Abstract »    PDF »
Penicillin-Induced Segmental Myoclonus: II. Membrane Properties of Cat Spinal Motoneurons.
L. I. Kao and W. E. Crill (1972)
Arch Neurol 26, 162-168
   Abstract »    PDF »


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