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Science 26 February 1971:
Vol. 171. no. 3973, pp. 809 - 812
DOI: 10.1126/science.171.3973.809
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Articles

Receptors: Localization and Specificity of Binding of Serotonin in the Central Nervous System

Spyridon G. A. Alivisatos 1, Frieda Ungar 1, Prahlad K. Seth 1, Leroy P. Levitt 1, Anthony J. Geroulis 1, and Thomas S. Meyer 1

1 Department of Biochemistry, Chicago Medical School, 2020 West Ogden Avenue, Chicago, Illinois 60612

Formation of a Schiff base between the ethylamine residue of serotonin and an appropriate carbonyl residue at the receptor site may be among the forces holding serotonin onto the receptor. Reduction of this imine may provide a means of permanently labeling receptors as a preliminary to their isolation.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)