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Science 29 January 1971:
Vol. 171. no. 3969, pp. 409 - 411
DOI: 10.1126/science.171.3969.409
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Articles

Favism: Association with Erythrocyte Acid Phosphatase Phenotype

Egidio Bottini 1, Paola Lucarelli 1, Rocco Agostino 1, Ricciotti Palmarino 1, Luisa Businco 1, and Giuseppina Antognoni 1

1 Centro di Genetica Evoluzionistica del CNR (Istituto di Genetica della Facoltà di Scienze) and Clinica Pediatrica dell'Università di Roma, Rome, Italy

The frequency of carriers of the Paand Pc alleles of the gene for acid phosphatase in the erythrocyte is significantly higher in male subjects deficient in glucose-6-phosphate dehydrogenase and having hemolytic clinical favism than it is in the general population. This observation seems to indicate that alleles (Pa and Pc) of a gene polymorphic in all human populations affect the fitness of the involved phenotypes in special genotypic and nongenotypic conditions.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Discrepancies between genotype and phenotype in hematology: an important frontier.
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Association Between ACP1 and Favism: A Possible Biochemical Mechanism.
E. Bottini, F. G. Bottini, P. Borgiani, and L. Businco (1997)
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