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Science 29 January 1971:
Vol. 171. no. 3969, pp. 394 - 397
DOI: 10.1126/science.171.3969.394
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Articles

Epithelial Origin of Polyoma Salivary Tumors in Mice: Evidence Based on Chromosome-Marked Cells

C. J. Dawe 1, J. Whang-Peng 1, W. D. Morgan 1, E. C. Hearon, 1, and T. Knutsen 1

1 Laboratory of Pathology and Human Cell Biology Branch, National Cancer Institute, Bethesda, Maryland 20014

Trypsin dissection of epithelium from mesenchyme of salivary gland rudiments allows reassembly of glands having either epithelium or mesenchyme selectively marked by T6 chromosomes. Virus-induced tumors in such glands invariably bear the karyotype of the epithelial component. The method solves a specific example from a group of classical problems concerning epithelial as opposed to mesenchymal origin of neoplasms.


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The hippocampus mediates glucocorticoid-induced impairment of spatial memory retrieval: Dependence on the basolateral amygdala.
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Inductive Tissue Interactions in Mammalian Development.
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