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Science 29 January 1971:
Vol. 171. no. 3969, pp. 390 - 391
DOI: 10.1126/science.171.3969.390
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Articles

Hyperoxaluria in L-Glyceric Aciduria: Possible Pathogenic Mechanism

Hibbard E. Williams 1 and Lloyd H. Smith Jr. 1

1 Department of Medicine, University of California School of Medicine, San Francisco 94122

The effect of hydroxypyruvate on synthesis of oxalate and glycolate from glyoxylate was studied in in vitro preparations from normal human erythrocytes and leukocytes, rat liver, and with purified lactate dehydrogenase from beef heart. In the presence of reduced nicotinamide adenine dinucleotide, hydroxypyruvate stimulated the oxidation of glyoxylate to oxalate and decreased the reduction of glyoxylate to glycolate. These findings may explain the hyperoxaluria seen in L-glyceric aciduria (type II primary hyperoxaluria).

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Science. ISSN 0036-8075 (print), 1095-9203 (online)