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Science 29 January 1971:
Vol. 171. no. 3969, pp. 387 - 389
DOI: 10.1126/science.171.3969.387
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Articles

Induction of Liver Acetaldehyde Dehydrogenase: Possible Role in Ethanol Tolerance after Exposure to Barbiturates

Geoffrey Redmond 1 and Gerald Cohen 1

1 Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York 10032

Mice were injected twice a day for 4 days with saline or phenobarbital or ethanol. Treatment with phenobarbital, but not ethanol, increased the amount of liver acetaldehyde dehydrogenase activity. More rapid removal of acetaldehyde, which is a toxic metabolic intermediate of ethanol, may contribute to the alcohol tolerance exhibited by persons who use barbiturates regularly.


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Exposure of rats to alcohol in utero alters drug sensitivity in adulthood.
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Acetaldehyde oxidation by hepatic mitochondria: decrease after chronic ethanol consumption.
Y Hasumura, R Teschke, and C. Lieber (1975)
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