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Science 15 January 1971:
Vol. 171. no. 3967, pp. 208 - 210
DOI: 10.1126/science.171.3967.208
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Articles

Supraoptic Neurosecretory Cells: Adrenergic and Cholinergic Sensitivity

Jeffery L. Barker 1, John W. Crayton 1, and Roger A. Nicoll 1

1 Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032

Adrenergic and cholinergic agonists and antagonists were applied microelectrophoretically to over 700 neurons in the cat supraoptic nucleus, 20 percent of which were antidromically identified as neurosecretory cells. Norepinephrine uniformly depressed all sensitive cells. Acetylcholine caused both muscarinic depression and nicotinic excitation which were antagonized by atropine and dihydro-beta-erythroidine, respectively. These results support the hypothesis that norepinephrine and acetylcholine are directly involved in controlling the release of antidiuretic hormone.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Supraoptic nucleus of the Brattleboro rat has an altered afferent noradrenergic input.
J Scholer and J. Sladek Jr (1981)
Science 214, 347-349
   Abstract »    PDF »
Supraoptic Neurosecretory Cells: Adrenergic and Cholinergic Sensitivity.
J. L. Barker, J. W. Crayton, and R. A. Nicoll (1971)
Science 171, 208-210
   Abstract »    PDF »


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