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Science 15 January 1971:
Vol. 171. no. 3967, pp. 201 - 203
DOI: 10.1126/science.171.3967.201
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Articles

Carcinogen and Microsomal Membrane Interactions: Changes in Membrane Density and Ability to Bind Nucleic Acids

H. Kubinski 1 and Charles B. Kasper 1

1 Division of Neurosurgery and McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine, Madison 53706

DNA and synthetic copolymer polyribocytidylic-polyriboguanylic acid bind to microsomal membrane. The nucleic acid-membrane complex may be detected by centrifugation in cesium chloride density gradients. The density of the nucleic acid-membrane complex and, in certain cases, the amount of nucleic acid associated with the membrane was changed in the presence of various carcinogenic chemicals.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)