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Science 15 January 1971:
Vol. 171. no. 3967, pp. 178 - 179
DOI: 10.1126/science.171.3967.178
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Articles

Hydrocortisone-Mediated Increase of Norepinephrine Uptake by Brain Slices

James W. Maas 1 and Maija Mednieks 1

1 Illinois State Psychiatric Institute, 1601 West Taylor Street, Chicago 60612

Slices of cerebral cortex from the adult rat were incubated with and without hydrocortisone succinate, and their subsequent uptake of isotopically labeled norepinephrine was measured. Preincubation with hydrocortisone resulted in a statistically significant increase in the amount of exogenous norepinephrine taken up by the slices. Preincubation with corresponding concentrations of sodium succinate was without effect. The principal effect of the hydrocortisone-mediated increase in norepinephrine concentration is apparently on an active transport mechanism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Side Effects of Corticosteroid Therapy: Psychiatric Aspects.
M. H. M. Ling, P. J. Perry, and M. T. Tsuang (1981)
Arch Gen Psychiatry 38, 471-477
   Abstract »    PDF »
Norepinephrine Uptake into Cerebral Cortical Synaptosomes after One Fight or Electroconvulsive Shock.
B. L. Welch, E. D. Hendley, and I. Turek (1974)
Science 183, 220-221
   Abstract »    PDF »


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