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Science 15 January 1971:
Vol. 171. no. 3967, pp. 176 - 178
DOI: 10.1126/science.171.3967.176
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Articles

Release of Nuclear DNA Template Restrictions by Specific Polyribonucleotides

David G. Brown 1 and Donald S. Coffey 1

1 Department of Pharmacology and Experimental Therapeutics, Johns Hopkins University School of Medicine, and James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland 21205

Certain synthetic homo- and copolyribonucleotide polymers are capable of releasing the DNA template restriction of isolated nuclei of rat liver cells when assayed with an excess of or in the absence of exogenous DNA polymerase. The purine homopolyribonucleotides are far more effective than are the pyrimidine polymers.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)