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Science 8 January 1971:
Vol. 171. no. 3966, pp. 77 - 79
DOI: 10.1126/science.171.3966.77
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Articles

Repression of Interferon Action: Induced Dedifferentiation of Embryonic Cells

Sidney E. Grossberg 1 and Page S. Morahan 1

1 Department of Microbiology, Medical College of Wisconsin, Milwaukee 53233

Cells cultured from young (6-day) chicken embryos differ from those of older (13-day) embryos in having a greater susceptibility to infection by certain viruses and a considerably lesser sensitivity to the action of interferon. These circumstances parallel those observed in the intact embryo. The addition of a small percentage of cells from young embryos alters the response of cells cultured from older embryos by increasing viral susceptibility sevenfold and decreasing sensitivity to interferon 25-fold. We postulate that a repressor which inhibits the expression of interferon in older embryonic cells is elaborated by cells from young embryos.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mouse Leukemia: Depression of Serum Interferon Production.
J. De Maeyer-Guignard (1972)
Science 177, 797-799
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