Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 11 December 1970:
Vol. 170. no. 3963, pp. 1212 - 1213
DOI: 10.1126/science.170.3963.1212
Prev | Table of Contents | Next

Articles

Parkinson's Disease: Activity of L-Dopa Decarboxylase in Discrete Brain Regions

K. Lloyd 1 and O. Hornykiewicz 1

1 Department of Pharmacology, University of Toronto, and Clarke Institute of Psychiatry, Toronto, Ontario, Canada

The activity of L-dopa decarboxylase was greatly reduced in the striatum, less so in the hypothalamus, and unchanged in the cortex of brains of patients with Parkinson's disease. However, it appears that even in the striatum enough activity remained to allow for the formation of dopamine from L-dopa in patients treated with large doses of L-dopa.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Gene Therapy for Dopamine Replacement in Parkinsons Disease.
A. Bjorklund, T. Bjorklund, and D. Kirik (2009)
Science Translational Medicine 1, 2ps2
   Full Text »    PDF »
`Like a thief in the night' : the selectivity of degeneration in Parkinson's disease.
C. B. Saper (1999)
Brain 122, 1401-1402
   Full Text »    PDF »
The Nigrostriatal Dopaminergic System Assessed In Vivo by Positron Emission Tomography in Healthy Volunteer Subjects and Patients With Parkinson's Disease.
K. L. Leenders, E. P. Salmon, P. Tyrrell, D. Perani, D. J. Brooks, H. Sager, T. Jones, C. D. Marsden, and R. S. J. Frackowiak (1990)
Arch Neurol 47, 1290-1298
   Abstract »    PDF »
Cerebral Catecholamines After Levodopa Therapy.
M. Greer, G. H. Collins, and A. H. Anton (1971)
Arch Neurol 25, 461-467
   Abstract »    PDF »
Dopamine: Stimulation-Induced Release from Central Neurons.
K. Y. Ng, T. N. Chase, R. W. Colburn, and I. J. Kopin (1971)
Science 172, 487-489
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)