Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 November 1970:
Vol. 170. no. 3958, pp. 636 - 637
DOI: 10.1126/science.170.3958.636
Prev | Table of Contents | Next

Articles

Soluble HL-A7 Antigen: Localization in the beta-Lipoprotein Fraction of Human Serum

Ronald K. Charlton 1 and Chester M. Zmijewski 1

1 Division of Immunology, Duke University Medical Center, Durham, North Carolina 27706

The HL-A7 antigen of human leukocytes occurs as a soluble, low-density lipoprotein in the serum of HL-A7-positive individuals. Its presence in high concentration may inhibit direct leukocyte grouping, leading to erroneous results. This finding affords an easy method for the preparation of monospecific cytotoxic antiserums by absorption with serum fractions rather than leukocytes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Induction of Exosome Release in Primary B Cells Stimulated via CD40 and the IL-4 Receptor.
S. C. Saunderson, P. C. Schuberth, A. C. Dunn, L. Miller, B. D. Hock, P. A. MacKay, N. Koch, R. W. Jack, and A. D. McLellan (2008)
J. Immunol. 180, 8146-8152
   Abstract »    Full Text »    PDF »
Exosomes As a Short-Range Mechanism to Spread Alloantigen between Dendritic Cells during T Cell Allorecognition.
A. Montecalvo, W. J. Shufesky, D. Beer Stolz, M. G. Sullivan, Z. Wang, S. J. Divito, G. D. Papworth, S. C. Watkins, P. D. Robbins, A. T. Larregina, et al. (2008)
J. Immunol. 180, 3081-3090
   Abstract »    Full Text »    PDF »
Apoptosis of Antigen-Specific T Lymphocytes upon the Engagement of CD8 by Soluble HLA Class I Molecules Is Fas Ligand/Fas Mediated: Evidence for the Involvement of p56lck, Calcium Calmodulin Kinase II, and Calcium-Independent Protein Kinase C Signaling Pathways and for NF-{kappa}B and NF-AT Nuclear Translocation.
P. Contini, M. Ghio, A. Merlo, A. Poggi, F. Indiveri, and F. Puppo (2005)
J. Immunol. 175, 7244-7254
   Abstract »    Full Text »    PDF »
Recombinant dimeric MHC antigens protect cardiac allografts from rejection and visualize alloreactive T cells.
A. Fried, M. Berg, B. Sharma, S. Bonde, and N. Zavazava (2005)
J. Leukoc. Biol. 78, 595-604
   Abstract »    Full Text »    PDF »
Soluble HLA class I antigens in serum and synovial fluid from patients with rheumatoid arthritis and other arthropathies.
S. Munoz-Fernandez, J. Martin, E. Martin-Mola, M. C. Garcia-Rodriguez, M. Cantalejo, G. Fontan, and A. Ferreira (2001)
Rheumatology 40, 1365-1369
   Abstract »    Full Text »    PDF »
Indirect Allorecognition of Donor Class I and II Major Histocompatibility Complex Peptides Promotes the Development of Transplant Vasculopathy.
K. L. WOMER, J. R. STONE, B. MURPHY, A. CHANDRAKER, and M. H. SAYEGH (2001)
J. Am. Soc. Nephrol. 12, 2500-2506
   Abstract »    Full Text »    PDF »
Alloreactivity and apoptosis in graft rejection and transplantation tolerance.
N. Zavazava and D. Kabelitz (2000)
J. Leukoc. Biol. 68, 167-174
   Abstract »    Full Text »
Soluble human MHC class I molecules induce soluble Fas ligand secretion and trigger apoptosis in activated CD8+ Fas (CD95)+ T lymphocytes.
F. Puppo, P. Contini, M. Ghio, S. Brenci, M. Scudeletti, G. Filaci, S. Ferrone, and F. Indiveri (2000)
Int. Immunol. 12, 195-203
   Abstract »    Full Text »    PDF »
Soluble HLA Class I, HLA Class II, and Fas Ligand in Blood Components: A Possible Key to Explain the Immunomodulatory Effects of Allogeneic Blood Transfusions.
M. Ghio, P. Contini, C. Mazzei, S. Brenci, G. Barberis, G. Filaci, F. Indiveri, and F. Puppo (1999)
Blood 93, 1770-1777
   Abstract »    Full Text »    PDF »
Compositional Relatedness between Histocompatibility Antigens and Human Serum Lipoproteins.
K. Berg (1971)
Science 172, 1136-1138
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)