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Science 30 October 1970:
Vol. 170. no. 3957, pp. 555 - 556
DOI: 10.1126/science.170.3957.555
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Articles

Substrate-Induced Conjugation of Bilirubin in Genetically Deficient Newborn Rats

M. Michael Thaler 1

1 Department of Pediatrics, University of California, San Francisco 94122

Bilirubin appears to induce its own conjugation with glucuronide. Bilibrubin uridine diphosphate-glucuronyltransferase activity is relatively high at birth in heterozygous offspring of permanently jaundiced female rats. The postnatal development of the transferase is accelerated in hyperbilirubinemic heterozygotes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Imbalance Between Production and Conjugation of Bilirubin: A Fundamental Concept in the Mechanism of Neonatal Jaundice.
M. Kaplan, M. Muraca, C. Hammerman, F. F. Rubaltelli, M. T. Vilei, H. J. Vreman, and D. K. Stevenson (2002)
Pediatrics 110, e47-47
   Abstract »    Full Text »    PDF »
Fetal Exposure to Maternal Hyperbilirubinemia: Neonatal Course and Outcome.
F. Waffarn, S. Carlisle, I. Pena, J. E. Hodgman, and D. Bonham (1982)
Arch Pediatr Adolesc Med 136, 739-740
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Fetal Exposure to Maternal Hyperbilirubinemia: Neonatal Course and Outcome.
F. Waffarn, S. Carlisle, I. Pena, J. E. Hodgman, and D. Bonham (1982)
Arch Pediatr Adolesc Med 136, 416-417
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Phenobarbital and Neonatal Jaundice: The Need for More Knowledge.
T. R. C. Sisson (1971)
Clinical Pediatrics 10, 683-684
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